After witnessing a mafia hit in the Windy City, Connie (Nia Vardalos) and Carla (Toni Collette) blow town for some low-profile living in Los Angeles. They may have found the perfect cover when they land jobs as drag queens on the city's dinner theater circuit. But things get even more complex when they become big hits and Connie meets the guy of her dreams, Jeff (David Duchovny), for whom she'd like to be all woman.